BMD Loss After ART Initiation

At 96 weeks after ART initiation, BMD loss was significantly greater in patients with pretreatment CD4 counts <50 cells/mm³ than in those with counts ≥500 cells/mm³.

Although bone mineral density (BMD) is known to decrease in HIV-infected patients after antiretroviral therapy (ART) initiation, the relative contributions of pre-ART immune deficiency, immune reconstitution, and ART medications to this effect remain poorly defined.

To explore this issue, investigators pooled data from three ACTG studies of ART in treatment-naive patients in which serial whole-body, dual-energy x-ray absorptiometry (DXA) scans were performed. The studies spanned successive periods in the combination ART era (enrollment in 1998–1999, 2003–2004, and 2005–2007) and included various ART regimens.

The analysis involved 796 participants with baseline and 96-week DXA evaluations (83% men; median age, 39; median baseline CD4 count, 2…

Reviewing Author

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

BMD Loss After ART Initiation

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Reviewing Author