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Despite the potential for probiotics to be safe and effective for treatment and prevention of infant colic, studies have been inconsistent. Researchers performed a rigorous systematic review of English-language randomized-controlled trials of probiotics in infants younger than 3 months, pregnant women in the month before delivery, or both. The 12 studies meeting criteria included 1825 infants and were published in 2006–2013. Only two studies had low risk for bias (based on randomization, blinding, and baseline characteristics).
Only two (of 7) preventive trials (often with formula) showed significant reductions in mean daily crying time with probiotics compared with placebo. Three of five treatment studies in infants with diagnosed colic dem…