E. coli Sequence Type 131 Subclone H30 Infections in U.S. Veterans

At Veterans Affairs medical centers nationwide, sequence type 131 (usually the H30 subclone) accounted for 78% of fluoroquinolone-resistant and 64% of extended-spectrum β-lactamase–producing E. coli isolates.

Although Escherichia coli is a universal gut commensal, it is also a major cause of extraintestinal disease, including urinary tract infections and bacteremia. Recently, a specific genetic sequence type, ST131, was identified as accounting for much of the fluoroquinolone-resistant (FQ-R) and extended-spectrum β-lactamase (ESBL)-producing E. coli in the world.

The Department of Veterans Affairs (VA) operates the largest integrated healthcare system in the U.S. Researchers (2 of whom have patent applications relating to diagnostic tests for ST131 and other E. coli lineages) hypothesized that ST131 — and especially its subclone H30, which contains a gene variant for fimbrial adhesin — was contributing to antibiotic resistance of E. coli among i…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

E. coli Sequence Type 131 Subclone H30 Infections in U.S. Veterans

Topics

Reviewing Author