During the first 5 years, the two-dose program reduced varicella incidence in all age groups, including infants.
Between 1995 and 2005, the one-dose varicella vaccine regimen reduced varicella incidence by 90%. However, 15% to 20% of children do not respond to the first dose, and outbreaks have continued to occur in highly vaccinated school populations. In 2006, the Advisory Committee on Immunization Practices recommended a second booster dose for all children. These authors examined the effect of the two-dose program in two surveillance sites with diverse populations: Antelope Valley (AV), California (population >373,000), is 42% white, non-Hispanic and 40% white Hispanic and West Philadelphia (WP), Pennsylvania (population >272,000), is 74% black.
Between 2006 and 2010, 1183 cases of varicella were reported in AV and 345 in WP. During this period, va…
Reviewing Author
DisclosuresGrant/Research SupportNIH Institutional Clinical and Translational Science Award; Agency for Healthcare Research and Quality National Center for Pediatric Practice Based Research Learning; Patient-Centered Outcomes Research Institute
Editorial BoardsCurrent Problems in Pediatric Adolescent Healthcare
Leadership Positions in Professional Societies College of Physicians of Philadelphia (Board of Trustees)
DisclosuresGrant/Research SupportNIH Institutional Clinical and Translational Science Award; Agency for Healthcare Research and Quality National Center for Pediatric Practice Based Research Learning; Patient-Centered Outcomes Research Institute
Editorial BoardsCurrent Problems in Pediatric Adolescent Healthcare
Leadership Positions in Professional Societies College of Physicians of Philadelphia (Board of Trustees)