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Dear Readers,
This has been an exciting year for us, with organizational changes that are reflected in our new title: NEJM Journal Watch Infectious Diseases. We remain devoted to providing clinicians with the information they need to give their patients the best care — and, as part of NEJM Group, we are now poised to do that better than ever.
The top infectious diseases stories this year vary considerably, but some common themes are evident. First, novel therapies are important — fecal transplant for recurrent Clostridium difficile infection, dual β-lactam therapy for enterococcal endocarditis, and tenofovir treatment of hepatitis B virus infection with reversal of cirrhosis, for example. Second, the problem of antibiotic resistance is growing, complicating the treatment of many bacterial infections, including gonorrhea. Third, infection-control practices relating to compounding of medicinal agents need to be reevaluated, as was shown by a major outbreak of fungal infections in patients who received contaminated steroid injections. Fourth, the world of infectious diseases continues to expand with newly recognized pathogens, including the Middle East respiratory syndrome coronavirus.
Fungal Meningitis After a Contaminated Epidural Steroid Injection
HBV Treatment Reverses Cirrhosis
Donor Feces for Recurrent Clostridium difficile Infection
Agricultural Antibiotic Use and Antibiotic Resistance
Ampicillin plus Ceftriaxone for Enterococcus faecalis Endocarditis
Gonococcal Treatment Failure Due to Cephalosporin Resistance Now in North America
Novel Avian-Origin Influenza A (H7N9) Virus in China
Can Gloves and Gowns Prevent the Spread of Antibiotic-Resistant Bacteria?