HIV-infected patients who developed Graves disease after initiating ART had high levels of naive CD4-cell recovery, and developed clinical disease later than other immune reconstitution events.
Graves disease (GD), the most common cause of hyperthyroidism in the general population, has been reported in HIV-infected patients after initiation of antiretroviral therapy (ART) and has been postulated to represent a manifestation of immune reconstitution disease. Now, in a retrospective study, investigators have compared the features of immunologic recovery between 7 patients who developed GD and 14 matched controls who did not.
The GD patients were men aged 30 to 45. Their CD4 counts were low (median, 12 cells/mm3) before ART initiation and substantially higher (median, 513 cells/mm3) at the time of GD diagnosis. GD was diagnosed 17 to 46 months (median, 34) after ART initiation.
The absolute CD4-cell recovery was similar between the cas…
Reviewing Author
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)