Should Hyperglycemia in Critically Ill Children Be Tightly Controlled?

Tight glycemic control did not improve major clinical outcomes.

Hyperglycemia is associated with adverse outcomes in critically ill children. In a randomized, multicenter trial, researchers compared clinical outcomes and costs associated with tight glycemic control (intravenous insulin to maintain glucose levels of 72-126 mg/dL) or conventional control (intravenous insulin at blood glucose levels >216 mg/dL) in 1369 children (age, <16 years; 62% <1 year) at 13 intensive care units (ICUs). All children were receiving mechanical ventilation and vasoactive drugs following critical illness, injury, or major surgery (60% had cardiac surgery).

At 30 days, no between-group differences were found in number of days alive and free from mechanical ventilation or number of days in the ICU. Age did not affect these r…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Should Hyperglycemia in Critically Ill Children Be Tightly Controlled?

Topics

Reviewing Author