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Higher levels of self-reported physical activity have been associated with lower risk for cardiovascular (CV) morbidity and mortality. But no studies have documented this association when physical activity is measured objectively. In a randomized pharmacotherapy trial (NAVIGATOR trial; NEJM JW Cardiol Mar 14 2010), 9306 patients (age, ≥50) who were at high risk for diabetes and CV disease used pedometers to record their ambulatory activity for 7 consecutive days at the start of the study and again after 1 year on a lifestyle modification program. Researchers now report on the association between ambulatory activity — at baseline and after 1 year — and risk for adverse CV events (CV-related mortality, nonfatal stroke, or myocardial infarctio…