Severe Chronic Kidney Disease in HIV-Infected Patients

Current CD4-cell count and traditional non-HIV risk factors — but not the antiretrovirals used — were the strongest predictors.

HIV-infected individuals are at high risk for severe chronic kidney disease (sCKD), including advanced chronic kidney disease (aCKD) and end-stage renal disease (ESRD). Such renal dysfunction stems from many causes, but antiretroviral medications — most notably tenofovir — have been shown to play a role.

In a recent study involving DAD cohort members with at least three estimated glomerular filtration rate (eGFR) results since 2004 (total, 35,192 patients; 74% men; 48% white; median age at baseline, 41; median baseline CD4 count, 436 cells/mm³; median follow-up duration, 6.2 years), researchers explored the independent contribution of antiretrovirals to the development of sCKD.

During follow-up, 114 patients developed aCKD — defined as two co…

Reviewing Author

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Severe Chronic Kidney Disease in HIV-Infected Patients

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Reviewing Author