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On average, obese people have lower serum vitamin D levels and require higher doses of supplemental vitamin D to correct deficiency than do nonobese people. To examine dose-response effects, researchers randomized 62 adults with high body-mass index (BMI; (30–58 kg/m2) to receive 1000, 5000, or 10,000 IU of oral vitamin D3 daily for 5 months. The study was conducted during winter months in Nebraska (when skin synthesis of vitamin D is minimal). At baseline, mean serum hydroxyvitamin D (25[OH]D) level was 23 ng/mL.
A dose-response effect was noted. Mean serum 25(OH)D levels increased by 12 ng/mL, 28 ng/mL, and 48 ng/mL in the 1000, 5000, and 10,000 IU groups, respectively. However, participants varied widely in individual responses: The range…