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Patients who undergo colectomy and ileal pouch anal anastomosis (IPAA) for chronic ulcerative colitis commonly undergo surveillance examinations of their pouch. Although we know that an indication of colorectal neoplasia (vs. active colitis) for colectomy is one risk factor for developing neoplasia in the pouch and the cuff, few others are established. Now, investigators in the Netherlands have retrospectively examined outcomes of 1200 patients with inflammatory bowel disease who underwent IPAA.
After a median follow-up of 6.5 years, findings included:
Twenty-five patients (1.83%) developed pouch neoplasia, including 16 adenocarcinomas.
Cumulative incidences at 5, 10, 15, and 20 years after IPAA were 1.0%, 2.0%, 3.7%, and 6.9%, respectively, f…