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Helicobacter pylori causes gastric cancer, the second leading cause of cancer death in the world. However, in some populations with high prevalences of H. pylori, gastric cancer rates are low. In the current study, researchers investigated whether genetic variations in H. pylori strains and human host populations affect risk for gastric cancer.
Investigators recruited 292 patients receiving upper endoscopy for dyspeptic symptoms from two geographically distinct populations in Colombia: one from a mountainous region, of predominantly Amerindian ancestry, and with a high incidence of gastric cancer; the other from a coastal region, of predominantly African ancestry, and with a low incidence of gastric cancer. The prevalence of H. pylori was si…