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Sex steroids may play a preventive role in the genesis of primary open-angle glaucoma (POAG) by lowering intraocular pressure or protecting retinal ganglion cells. Using data from a nationwide managed-care claims database, investigators assessed the incidence of POAG in >150,000 women (mean age, 65; 81% white, 4% black, 4% Latina, 2% Asian-American) who used estrogen-alone therapy (ET) or estrogen-progestin therapy (EPT), or who never used menopausal hormone therapy (HT). Eligible enrollees had ≥2 visits to an eye care provider from 2001 through 2009.
Incidence of POAG was 2.1% in nonusers of HT, 1.9% in EPT users, and 1.7% in ET users. In adjusted multivariable analysis, the reduced incidence of POAG with ET use remained statistically signi…