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Helicobacter pylorus is an established cause of gastric cancer (GC). The effect of H. pylori eradication on subsequent development of metachronous tumors or dysplasia after endoscopic resection is controversial.
Investigators at a single center in Korea retrospectively assessed whether H. pylori infection eradication was associated with reduced risk for GC or dysplasia in 283 patients treated for early GC with endoscopic mucosal dissection (ESD). All patients were treated for H. pylori infection. Treatment failed in 69 patients. All patients were followed with endoscopy at 3, 6, and 12 months, and then annually for metachronous GC or dysplasia.
After at least 3 years of follow-up, metachronous GC or dysplasia occurred in 13 of 69 (18.8%) pati…