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Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is usually indolent, but transformation to aggressive behavior occurs in about 10% of cases. Because presence of CD20+ lymphoid cells is often associated with transformed MF, these investigators explored the importance of CD20 antigen in predicting aggressive behavior in MF.
In 148 cases of transformed MF, the authors analyzed the proportion, distribution, and size of the CD20+ lymphocytes. They also used anti-CD20 antibodies to investigate whether these cells were reactive or lymphomatous. CXCL-13 was used to investigate the role of the T-helper follicular (THF) phenotype in recruitment of B cells.
Over 80% of cases had a density of 10% to 49% CD20+ cells, and 12% involved mo…