Reinforcing the Value of Oophorectomy in Women with BRCA Mutations

Long-term data add confidence that oophorectomy prevents ovarian cancer and saves lives.

Although the current recommendation for care of women with BRCA mutations includes consideration of risk-reducing salpingo-oophorectomy, the optimal age at surgery and the extent of cancer risk reduction are unknown. In an ongoing prospective observational study of 5783 women with BRCA1 or BRCA2 mutations (mean age at oophorectomy, 47), investigators report extended follow-up (mean, 5.6 years).

Overall, 186 women received diagnoses of ovarian, fallopian, or peritoneal cancer; of these, 68 died. Prior bilateral oophorectomy was associated with 80% lower risk for these malignancies (P<0.001). Among cohort members with no known cancer at baseline, the all-cause mortality hazard ratio associated with oophorectomy was 0.23 (P<0.001). In 1390 wome…

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Reinforcing the Value of Oophorectomy in Women with BRCA Mutations

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Reviewing Author