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The International Prognostic Index (IPI) has been a powerful tool for predicting post-treatment outcomes and comparing results across clinical trials in diffuse large B-cell lymphoma (DLBCL) for more than 20 years. Given that rituximab has improved survival across all risk groups since the late 1990s, investigators have created a new prognostic model based on a retrospective analysis of 1650 newly diagnosed DLBCL patients who received induction rituximab-based chemotherapy from 2000 to 2010 at seven centers in the National Cancer Center Network (NCCN). The new NCCN-IPI was validated in an independent cohort of 1138 DLBCL patients treated at the British Columbia Cancer Agency.
Patients were scored on a maximum eight-point scale, according to …