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Genetic, anatomic, and behavioral research support a key role of impaired γ-aminobutyric acid (GABA) transmission in schizophrenia (e.g., Neuropsychopharmacology 2001; 25:1; and Schizophr Bull 2013 Dec 22) and of reduced glutamic acid decarboxylase 67 and GABA levels in the prefrontal cortex (PFC) of adult rats exposed to marijuana during adolescence (Neurobiol Dis 2014; 63:35). To expand these findings, researchers conducted electrophysiological experiments in rats that were injected peritoneally with an agonist of the cannabinoid 1 receptor (CB1). Exposure occurred daily for 5 days at one of four points — early adolescence, mid-adolescence, late adolescence, and adulthood.
When rats were adults, cannabinoid exposure during early and middle…