No Mortality Benefit from a Higher MAP Target in Septic Patients

A target mean arterial pressure of 80 to 85 mm Hg conferred no mortality benefit over the standard 65 to 70 mm Hg target.

Current sepsis guidelines recommend using fluids and vasopressors to maintain a mean arterial pressure (MAP) target of at least 65 mm Hg in patients with septic shock, as part of a sepsis treatment bundle that has been shown to confer a mortality benefit (NEJM Journal Watch Emerg Med Feb 22 2013 and NEJM Journal Watch Emerg Med Sep 7 2012). However, it is unknown whether a higher MAP target might improve mortality and decrease end-organ dysfunction. In a 29-center French study, researchers compared outcomes in 776 patients with septic shock who were randomized to MAP targets of either 65 to 70 mm Hg or 80 to 85 mm Hg.

The actual measured range of MAP values was about 5 mm Hg higher than the target ranges in both groups. There were no signifi…

Reviewing Author

Ali S. Raja, MD, MBA, MPH, FACEP

Disclosures

Leadership Positions in Professional SocietiesSociety for Academic Emergency Medicine (Board Member); American College of Healthcare Executives – Massachusetts (Board Member)

Ali S. Raja, MD, MBA, MPH, FACEP

Disclosures

Leadership Positions in Professional SocietiesSociety for Academic Emergency Medicine (Board Member); American College of Healthcare Executives – Massachusetts (Board Member)

No Mortality Benefit from a Higher MAP Target in Septic Patients

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Reviewing Author