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The rate of HIV-associated nephropathy (HIVAN) was increasing in the U.S., particularly among blacks, before the availability of combination antiretroviral therapy. Use of such therapy has greatly improved the overall outlook for HIV-infected patients, but how has it affected rates of HIVAN?
To answer this question, researchers examined the temporal trends in end-stage renal disease (ESRD; defined as use of renal replacement therapy [RRT], such as dialysis) in HIV-infected patients from 2001 through 2010. Using files from the U.S. Renal Data System, which systematically collects, analyzes, and distributes information about ESRD in the U.S., including information from Medicaid and Medicare, they analyzed basic laboratory and demographic data …