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The management of idiopathic normal-pressure hydrocephalus (iNPH) is difficult because the diagnosis is often uncertain and treatment with shunt surgery carries significant risk. Doctors are reluctant to make the diagnosis of iNPH, probably because none of the cardinal findings (such as gait difficulty, cognitive decline, incontinence of urine, and enlarged ventricles) is pathognomonic. To assess the effect of low-dose acetazolamide (125–375 mg daily) on volumetric magnetic resonance imaging (MRI) markers and clinical outcomes, researchers retrospectively analyzed MRI and gait measures from eight patients with iNPH. The researchers used automated analysis to quantify each patient's ventricular volume and global and periventricular white mat…