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In patients with cirrhosis who develop hepatorenal syndrome (HRS), especially type 1, morbidity and mortality are high. In many instances, the development of HRS is precipitated by bacterial infection, but little is known about outcomes and survival in this subgroup of patients.
From a large, prospective cohort study assessing kidney failure in patients with cirrhosis, researchers identified a subset of 70 patients with HRS type 1 with infection. HRS type 1 was defined as an increase in serum creatinine of >100% from baseline with a final value >2.5 mg/dL in less than 2 weeks without another cause identified. The infection had to be ongoing and without the presence of septic shock. Main outcomes were no reversibility of HRS type 1 (no decrea…