Diagnosis of Childhood TB in Africa

Researchers identified a tuberculosis-specific transcriptome signature in host blood that helped to distinguish tuberculosis from other diseases with similar clinical features.

Tuberculosis (TB) remains a heavy burden in many areas of the world, particularly those with high rates of HIV infection. In children, the disease is often diagnosed solely on clinical grounds. The signs and symptoms of childhood TB are similar to those of several other conditions, however, and misdiagnosis commonly occurs, leading to delays in administering appropriate therapy and the unnecessary use of antimicrobials. Diagnostic advances are sorely needed, especially in sub-Saharan Africa, where TB is a major public health problem. In a recent study, researchers investigated the use of genome-wide RNA expression in host blood to distinguish TB from other illnesses common among children in the region.

Children aged <15 years with symptoms s…

Reviewing Author

Larry M. Baddour, MD

Disclosures

RoyaltiesUpToDate, Inc. (Authorship duties)

Larry M. Baddour, MD

Disclosures

RoyaltiesUpToDate, Inc. (Authorship duties)

Diagnosis of Childhood TB in Africa

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Reviewing Author