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Survival after allogeneic stem-cell transplantation (SCT) is dependent on many factors including the aggressiveness of the malignancy, the age and comorbidities of the recipient, and the transplant match and conditioning regimen. A disease-risk index (DRI) based on disease type and severity was developed by a single institution (Blood 2012; 120:905), but its applicability to other centers and patient populations was unclear.
To refine and expand the DRI in the multicenter setting, investigators from the Center for International Blood and Marrow Transplant Research collected data on 13,131 patients who underwent SCT between 2008 and 2010. Hematologic malignancies were grouped into four risk categories as follows; 2-year overall survival (OS) …