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The bleeding score (BS) assigns points based on the history and intensity of bleeding, with 1 for trivial or no bleeding, increasing to 4 for hemorrhage that is spontaneous or requires transfusion (J Thromb Haemost 2006; 4:766). Patients with the most serious bleeding disorders usually have scores >10.
To determine whether the BS predicts clinical outcomes in patients with von Willebrand disease (VWD), investigators analyzed data collected over 12 months in 796 patients prospectively recruited by the Italian Association of Hemophilia Centers. The main observations were as follows:
The hazard ratio for bleeding, adjusted for age and sex, was 2.1 (95% confidence interval, 1.1–3.9) for a BS of 5–10 and 6.8 (95% CI, 3.8–12.3) for a score >10. The…