Sex Differences in Coronary Microvascular Dysfunction?

The prevalence and implications of CMD are similar in both men and women and could serve as a useful marker of risk.

Coronary microvascular dysfunction (CMD) is common and associated with adverse outcomes in patients with symptoms suggestive of coronary artery disease (CAD). To assess sex differences in the prevalence and effects of CMD, investigators identified 405 men and 813 women referred for evaluation of suspected CAD with no history or visual evidence (on positron emission tomography myocardial perfusion imaging) of obstructive disease.

The rate of CMD, defined as a calculated coronary flow reserve (CFR) of <2.0, was 51% in men and 54% in women, a nonsignificant difference. In both sexes, CFR was a continuous predictor of major adverse cardiac events (cardiac death, nonfatal myocardial infarction, late revascularization, and hospitalization for hear…

Reviewing Author

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

Sex Differences in Coronary Microvascular Dysfunction?

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Reviewing Author