How Has Community-Associated MRSA Spread?

The use of whole-genome sequencing provided insights into the evolution and transmission patterns of community-associated methicillin-resistant Staphylococcus aureus in New York City.

The emergence of the USA300 community-associated strain of methicillin-resistant Staphylococcus aureus (CA-MRSA) has led to a marked increase in staphylococcal skin and soft tissue infections. Although several unique virulence determinants have been defined for this strain, the factors underlying its rapid spread are not understood. To shed light on the topic, investigators analyzed a large collection of epidemiologically well-characterized CA-MRSA isolates from New York City.

Full-genome sequencing was performed on 387 CA-MRSA isolates collected from 161 individuals between 2009 and 2011 in Manhattan and the Bronx. These data — together with published sequences of additional CA-MRSA strains identified from New York City, California, and Tex…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

How Has Community-Associated MRSA Spread?

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Reviewing Author