Providing neonates with hepatitis B vaccine and immune globulin is highly effective.
Universal screening of pregnant women for chronic hepatitis B infection followed by administration of hepatitis B immunoglobulin and vaccine to neonates of infected women is recommended. Investigators analyzed the Kaiser Permanente Northern California electronic database from 1997 to 2010 to assess adherence to and effectiveness of these practices.
Among 3253 women with chronic hepatitis B infection, 4446 offspring were identified. Over the entire study period, 87% of these mothers were tested for hepatitis B e antigen (an indicator of infectivity), 93% were tested for viral load prior to delivery, and 87% of the children received timely immune prophylaxis. Perinatal hepatitis B transmission occurred in 0.75% of births; in all but one, mothe…
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)