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Ulipristal acetate (UPA; 30 mg) is a relative newcomer to the arena of emergency contraception (EC). In a manufacturer-funded study, researchers used international postmarketing surveillance data (>1,400,000 women; October 2009 to May 2013) to further explore the safety and tolerability of UPA.
A total of 553 women reported 1049 adverse drug reactions associated with UPA. Pregnancy occurred in 282 UPA users; combined with the 94 pregnancies that were observed in clinical trials, a total of 376 exposed pregnancies occurred. Among 232 pregnancies with known outcomes, 151 resulted in induced abortions, 28 resulted in uncomplicated live births, and rates of first-trimester miscarriage and ectopic pregnancy compared favorably with those in the ge…