Genotypic Risk for Celiac Disease Early in Life

Children who were homozygous for HLA haplotype DR3-DQ2 were at 5.7 times greater risk for celiac autoimmunity compared with children who had low-risk genotypes.

Celiac disease is an autoimmune condition that is associated with the presence of specific HLA haplotypes (DR3-DQ2 and DR4-DQ8) on chromosome 6. To determine the relative risk for developing celiac autoimmunity and celiac disease in children born with these haplotypes, investigators analyzed prospective data on 6403 children enrolled in an international study (The Environmental Determinants of Diabetes in the Young) before age 4.5 months.

At a median follow-up of 60 months, 786 children (12%) had developed celiac disease autoimmunity, defined as persistent presence of tissue transglutaminase (tTG) antibodies in consecutive blood tests taken at least 3 months apart. Small-intestine biopsies confirmed celiac disease in 291 of 350 children. In …

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Genotypic Risk for Celiac Disease Early in Life

Topics

Reviewing Author