Invasive Pneumococcal Disease After PCV13

Despite a significant decline primarily in healthy children, most remaining cases are in children with underlying conditions and more likely to be hospitalized.

Introduction of 7-valent conjugate pneumococcal vaccine (PCV7) in 2000 led to significant (>50%) reductions in the incidence of invasive pneumococcal disease (IPD) in the U.S. (NEJM JW Pediatr Adolesc Med May 9 2003). However, IPD caused by nonvaccine serotypes (specifically 19A) increased, prompting development of PCV13. In a population-based observational study, investigators examined the effect of PCV13 among children aged ≤5 years in Massachusetts before (2007–2009; 168 cases) and after (2010–2012; 85 cases) introduction of PVC13.

Although introduction of PVC13 was associated with a 50% decrease in the number of IPD cases, the proportion of cases with chronic underlying conditions increased by 17% (a nonstatistically significant increase…

Reviewing Author

Deborah Lehman, MD

Disclosures

Nothing to disclose

Deborah Lehman, MD

Disclosures

Nothing to disclose

Invasive Pneumococcal Disease After PCV13

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Reviewing Author