Matching Patients and Donors for Stem-Cell Transplantation

Identifying highly matched donors remains a challenge for most nonwhite populations.

Allogeneic hematopoietic stem-cell transplantation (HSCT) represents the only curative approach for many patients with high-risk or relapsed hematologic malignancies. However, only about 30% of patients have a human leukocyte antigen (HLA)-matched related donor.

To assess the likelihood of identifying unrelated-matched (8/8 HLA loci) or minimally mismatched (7/8 loci) donor or cord blood in the U.S. National Marrow Donor Program (NMDP), investigators used a population-based model to determine the frequency of donor availability among 21 racial and ethnic groups. The NMDP registry contains approximately 11 million donors and nearly 200,000 cord-blood units. The latter require less-stringent matching (6/6 or 5/6 loci), but single-cord units of…

Reviewing Author

Michael E. Williams, MD, ScM

Disclosures

Consultant/Advisory BoardAbbVie; AstraZeneca; Beigene; Janssen; Pharmacyclics

Grant/Research SupportJanssen

Editorial BoardsAmerican Board of Internal Medicine (ABIM) Hematology Longitudinal Knowledge Approval Committee

Michael E. Williams, MD, ScM

Disclosures

Consultant/Advisory BoardAbbVie; AstraZeneca; Beigene; Janssen; Pharmacyclics

Grant/Research SupportJanssen

Editorial BoardsAmerican Board of Internal Medicine (ABIM) Hematology Longitudinal Knowledge Approval Committee

Matching Patients and Donors for Stem-Cell Transplantation

Topics

Reviewing Author