Risk Factors for NSAID-Associated Small Bowel Lesions

Comorbidities and type of NSAID affected risk but pharmacogenetics did not.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with small-bowel injuries ranging from increased mucosal permeability to large ulcerations or mucosal diaphragms. Because NSAIDs are metabolized by the cytochrome CYP2C9 enzyme, genetic polymorphisms may decrease the metabolism of this class of drugs, thus increasing its potential for causing adverse effects.

To assess the risk factors for symptomatic, NSAID-associated, small-bowel lesions, investigators in Japan retrospectively evaluated the results of video capsule endoscopy (VCE) or double-balloon endoscopy (DBE) in 1262 symptomatic patients referred to a single hospital.

Among the 156 NSAID users in the study, 31 (20%) had lesions detected by VCE or DBE. In multivariate analysis…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Risk Factors for NSAID-Associated Small Bowel Lesions

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Reviewing Author