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As the size of genetic studies of schizophrenia increases, so does the number of common single nucleotide polymorphisms (SNPs) identified, as Flint and Munafò have noted. To capitalize on this, investigators analyzed data from all known published and unpublished genome-wide association studies of schizophrenia.
Subjects included 36,989 schizophrenia cases and 113,075 controls. The researchers avoided confounding within populations by ancestry-matching patients and controls. Genotyping included 9.5 million variants.
Overall, 108 loci were associated with schizophrenia; 83 were newly discovered. Although studies used differing methods of ascertainment and diagnosis, their findings were similar, indicating that methodological differences did not…