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Co-occurrence of alcohol use disorders and post-traumatic stress disorder (PTSD) is common and leads to poorer outcomes and functioning than either disorder alone. Based on demonstrated efficacy of topiramate for each disorder, these researchers tested the effects of adjunctive use of the drug in 30 veterans with current DSM-IV-TR PTSD and alcohol dependence (28 men; mean age, 50) who expressed the desire to reduce their alcohol consumption.
The 12-week, randomized, controlled study used flexible dosing (25–300 mg daily). Attrition was low (10%) and similar in both groups. Mean daily topiramate dose was 286 mg. Compared with baseline and with placebo, topiramate significantly reduced the number of drinking days and craving for alcohol and sh…