Which Children Develop Renal Scarring After One UTI?

Children with abnormal renal ultrasound findings or fever ≥39°C and an etiologic organism besides Escherichia coli are at somewhat higher risk.

Renal scarring can be a permanent consequence of urinary tract infection (UTI), and is associated with long-term conditions such as decreased renal function and hypertension. Investigators determined prognostic factors for renal scarring in a pooled analysis of individual data from 1280 children in nine studies (age range, 0–15 years) with first-time UTIs.

Based on results of dimercaptosuccinic acid (DMSA) scans performed at least 5 months after the first UTI, 16% of children had renal scarring. Odds ratios for renal scarring were significantly elevated in children with abnormal renal ultrasound findings (OR, 3.8), C-reactive protein >4 mg/dL (3.0), fever ≥39°C (2.3), etiologic organism other than Escherichia coli (2.2), polymorphonuclear ce…

Reviewing Author

Cornelius W. Van Niel, MD

Disclosures

EquityMedtronic; Express Scripts; Johnson & Johnson; Merck

Cornelius W. Van Niel, MD

Disclosures

EquityMedtronic; Express Scripts; Johnson & Johnson; Merck

Which Children Develop Renal Scarring After One UTI?

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Reviewing Author