Stimulation that uses optogenetics is associated with multiple changes.
Brain stimulation techniques, such as transcranial magnetic stimulation (TMS), have been explored as possible treatment to promote recovery after injury, but they are imprecise tools; stimulation or inhibition of neurons, astrocytes, and oligodentrocytes occurs in a relatively large area. The technique of optogenetics (NEJM JW Psychiatry Jun 27 2013) enables the stimulation of only one cell type in the affected area. The current study involves stimulating neurons in the primary motor cortex on the side of an experimental stroke lesion in mice.
Control groups were stroke mice without stimulation, healthy mice with or without stimulation, and sham-surgery mice. Stimulation on poststroke days 5 through 14 involved three 1-minute pulses, with 3 …
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)