Optimal Vitamin D Levels May Improve IVF Outcomes

In a prospective Italian study, women with higher serum vitamin D levels had higher pregnancy rates than those with suboptimal levels.

Vitamin D plays a well-known role in mammalian reproductive function, but do vitamin D levels affect pregnancy rates in cycles involving in vitro fertilization (IVF)? Investigators at an Italian fertility center conducted a prospective cross-sectional study to assess IVF outcomes in women (age range, 18–42; body-mass index, 18–25 kg/m²; adequate ovarian reserve) with serum 25-hydroxy-vitamin-D (25[OH]D) levels <20 ng/mL compared with those having levels ≥20 ng/mL. (Levels of 20–40 ng/mL are generally considered optimal.)

Among 335 eligible participants, 154 had 25(OH)D levels <20 ng/mL and 181 had levels ≥20 ng/mL. Although similar numbers of oocytes were obtained and embryos transferred in both groups, the women with higher 25(OH)D levels h…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Optimal Vitamin D Levels May Improve IVF Outcomes

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Reviewing Author