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Recurrent Clostridium difficile infection (CDI) is experienced by approximately 20% of patients who suffer initial CDIs. Preventing recurrent CDIs, potentially with novel therapies, rests on our ability to identify high-risk patients during their initial presentations.
In a single-institution, retrospective cohort study, researchers developed a bedside prediction model for recurrent CDI, based on risk factors that are readily identifiable during initial CDI episodes. Recurrent CDI was defined as a positive toxin assay within 42 days of treatment for an initial episode of CDI. Between 2003 and 2010, approximately 4200 patients suffered initial CDIs, and 10% developed recurrent CDIs. In a multivariate analysis, six factors (community-onset, he…