Drug-Induced Liver Injury from Statins Is Rare and Self-Limited

However, injuries with autoimmune features might be more likely to become chronic.

Up to 3% of patients taking HMG-CoA reductase inhibitors (statins) develop mild liver-enzyme elevations and, although rare, clinically apparent drug-induced liver injury (DILI). To examine the relationship between dose and duration of statin use and risk for DILI as well as long-term outcomes, investigators described 22 patients with DILI attributed to statin use. The cohort was selected from 1188 patients in the U.S. DILI Network prospective registry study and had been followed for ≥6 months. Results included the following:

The latency of onset of liver injury ranged from 34 days to 10 years.
Median initial levels of alanine aminotransferase and alkaline phosphatase were 892 IU/L and 338 IU/L, respectively.
The median peak level of total bili…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Drug-Induced Liver Injury from Statins Is Rare and Self-Limited

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Reviewing Author