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Compared with cervical cytology, human papillomavirus (HPV)-based testing might be more effective in screening for cervical intraepithelial neoplasia (Lancet 2014; 383:524). Urine-based HPV testing is emerging as an alternative to cervical sampling — and many women would prefer providing urine specimens to undergoing vaginal speculum examinations. In this systematic review and meta-analysis of 14 studies that involved >1400 sexually active women, investigators determined the accuracy of testing urine for HPV DNA to detect cervical HPV infection.
Compared with cervical testing, urinary detection of any HPV had a sensitivity of 87% and a specificity of 94%. Detection of high-risk HPV had a sensitivity of 77% and a specificity of 88%, and detec…