Zoster Vaccine Effective When Given Before Immunosuppression in Older Adults

In a cohort study involving more than 20,000 individuals aged ≥60, vaccination prior to immunosuppression reduced the incidence of subsequent herpes zoster by nearly 42%.

Age and immunosuppression are major risk factors for the development of herpes zoster (HZ). Although zoster vaccine has been shown to be safe in immunocompetent older individuals, it is contraindicated in those with immunosuppression because it contains live attenuated virus and data on safety and efficacy in such patients are limited. However, most immunosuppression in adults is acquired, and it is unclear whether zoster vaccination administered at an earlier time confers protection from HZ once immunosuppression has occurred.

To examine this issue, researchers conducted a cohort study among Kaiser Permanente Southern California healthcare system members aged ≥60 who had received chemotherapy with myelosuppressive agents between January 200…

Reviewing Author

Neil M. Ampel, MD

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Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Zoster Vaccine Effective When Given Before Immunosuppression in Older Adults

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Reviewing Author