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Some clinicians prescribe testosterone for middle-aged and older men who have vague symptoms and low-normal total blood testosterone levels. In this placebo-controlled, randomized trial from Australia, researchers examined the effect of treatment with long-acting intramuscular testosterone undecanoate (Aveed) in 88 men with type 2 diabetes and total testosterone levels between 144 and 346 ng/dL. The primary outcome was the score on a standardized 17-item questionnaire (Aging Male Symptoms [AMS] scale), which includes somatic, psychological, and sexual items. Most patients' baseline scores were in the mild-to-moderate range of severity.
Testosterone supplementation increased mean blood testosterone by about 170 ng/dL. However, at 18 and 40 we…