Lipodystrophy in the Combination Antiretroviral Therapy Era — Encouraging Trends

In a contemporary cohort of patients with chronic HIV infection, leg and intra-abdominal fat increases over time were not associated with cumulative antiretroviral exposure.

Lipodystrophy associated with HIV infection and specific antiretrovirals has been a prominent concern, but the issue has received less attention lately. In a recent observational study, 1840 patients with chronic HIV infection (66% male; mean baseline age, 45; mean duration of HIV infection, 14 years) treated between 2005 and 2012 at an Italian referral center for HIV-associated metabolic problems were evaluated for trends in fat distribution over time. All patients had been on antiretroviral therapy (ART) for >18 months and had undergone at least two anthropometric evaluations involving dual energy x-ray absorptiometry (DEXA) to determine leg fat percentage and computed tomography (CT) to quantify visceral adipose tissue (median, 4 DEXA an…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Lipodystrophy in the Combination Antiretroviral Therapy Era — Encouraging Trends

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Reviewing Author