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Current guidelines support dual antiplatelet treatment with aspirin and thienopyridines (e.g., clopidogrel) for patients with unstable angina or non–ST-segment elevation myocardial infarction (NSTEMI), because older randomized trials showed benefits. However, some newer trials and registry analyses (some using other agents, such as prasugrel [Effient]) have failed to reveal benefits. In this meta-analysis, the authors combined data from available randomized trials and from registries to assess the effect of thienopyridine treatment (particularly pretreatment that occurred early in hospitalizations or prior to cardiac angiography) on outcomes, both in patients who underwent subsequent percutaneous interventions (PCIs) and in those who were t…