Statin Use Beneficial Only in Gram-Negative Infections?

Results from a prospective, observational study suggest a protective effect of prior statin use on mortality from gram-negative — but not gram-positive — bloodstream infections.

Several previous investigations have suggested that prior statin use has a protective effect on sepsis outcome (NEJM JW Infect Dis Feb 14 2007). However, such studies were often limited by small sample size and uncontrolled design, leaving opportunity for confounders such as failure to differentiate between gram-positive and gram-negative infections.

To address one such issue, researchers in Norway conducted a prospective, observational study involving adults with bloodstream infections (BSIs; 746 gram-negative and 572 gram-positive) who were treated at their institution between 2002 and 2011. Eighteen percent of those with gram-negative and 17% of those with gram-positive BSIs had taken statins the week preceding the positive blood culture.…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Statin Use Beneficial Only in Gram-Negative Infections?

Topics

Reviewing Author