Touching upon Systemic Disease in Palpable Purpura

Extracutaneous involvement was common in children with HSP.

Henoch-Schönlein purpura (HSP) is commonly associated with disease in other organs, especially joints, kidneys, and gastrointestinal tract. Sometimes, only skin is involved. Factors associated with increased risk for systemic disease in children include older age, involvement of scrotal skin, severe abdominal pain, increased serum levels of immunoglobulin A (HSP is an IgA-mediated immune complex vasculitis), and relapse. Factors associated with increased risk for systemic disease in adults include purpura above the waist, recent history of infection, fever, absence of perivascular eosinophils, and summer onset.

These authors retrospectively characterized clinical, histopathologic, and direct immunofluorescence findings in 34 children with HS…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)