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Antimicrobial resistance is a serious and increasing problem in treating infections; reducing unnecessary antimicrobial use is believed to be one of the most effective ways to retard the process. The CDC has recommended that clinicians take periodic time-outs to reconsider the type, dose, and duration of antibiotics that hospitalized patients are receiving — so-called “antibiotic self-stewardship.” To investigate the effects of this strategy, researchers compared the use of selected antibiotics and the incidence of nosocomial Clostridium difficile infection before and after the implementation of mandatory time-outs in two 23-bed inpatient units of a Montreal hospital.
Baseline use of carbapenems, moxifloxacin, piperacillin-tazobactam, and va…