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Is the psychological stress of undergoing fertility treatment augmented by the possible biological effects on mood from the administration of drugs that manipulate the level of gonadotropin hormone? Researchers receiving some industry support examined emotional changes in 83 women randomized to receive fertility treatment using either an agonist or antagonist of gonadotropin-releasing hormone. Participants completed a standardized personality inventory at baseline, as well as various self-report measures (mood-state profile, mental distress checklist, and depression inventory) that were repeated throughout the fertility protocols.
No participants had elevated scores on any measure at baseline. At multiple follow-ups, symptoms of distress did…