In HIV-infected and -uninfected men, elevated levels of monocyte activation markers were associated with subclinical atherosclerosis.
There is a substantial body of evidence linking HIV infection to increased rates of cardiovascular disease (CVD), but the mechanism is not certain. Now, researchers have evaluated the role of monocyte activation in coronary artery atherosclerosis in HIV-infected and -uninfected men in the MACS cohort.
A total of 906 men (566 HIV-infected, 340 HIV-uninfected) underwent noncontrast cardiac computed tomography (CT) to assess coronary artery calcium levels; 709 (426 HIV-infected, 283 HIV-uninfected) also had coronary CT angiography to evaluate for coronary artery stenosis and coronary plaque. Levels of the monocyte activation markers, soluble CD163 (sCD163) and soluble CD14 (sCD14), and a proinflammatory chemokine — monocyte chemoattractant prot…
Reviewing Author
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)